intermittent clonazepam in the prevention of recurrent febrile seizures
نویسندگان
چکیده
objective to evaluate the efficacy and common side effects of intermittent clonazepam in febrile seizures. materials & methods this study was an experimental trial designed to determine the efficacy of intermittent clonazepam in febrile seizures .thirty patients with an age range of 6 months to 5 years (60% male, 40% female) were studied. children with a history of psychomotor delay, abnormal neurological examination, a history of antiepileptic drug consumption, and afebrile seizures were excluded from the study. patients received a single dose of prophylactic clonazepam (0.05 mg/kg/ day) on the first day of febrile illness and twice daily during the course of fever. an antipyretic medication (acetaminophen) was advised if fever exceeded 38oc. patients were followed up for one year after the study inclusion date. results three patients were excluded from study since they didnot follow the tritment and three patients experienced afebrile seizures. twenty four patients had 162 febrile episodes during the course of the study and all patients were seizure-free after 1 year. conclusion clonazepam was 100% effective but lethargy and ataxia were common side effects in patients. fortunately, their parents continued treatment because they had prior awareness of the possible side effects of clonazepam. clonazepam is efficacious as an intermittent therapy for febrile seizures if parents are informed of its side effects.
منابع مشابه
Treatment of febrile seizures with intermittent clobazam.
Fifty children, 24 female and 26 male, with ages varying from 6 to 72 months (mean = 23.7 m.) that experienced at least one febrile seizure (FS) entered a prospective study of intermittent therapy with clobazam. Cases with severe neurological abnormalities, progressive neurological disease, afebrile seizures, symptomatic seizures of other nature, or seizures during a central nervous system infe...
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OBJECTIVE To compare the effectiveness of intermittent clobazam versus diazepam therapy in preventing the recurrence of febrile seizures and assess adverse effects of each drug. METHODS This prospective randomized controlled trial was performed on neurologically normal children aged from 6 months to 5 years with a history of simple febrile seizures and normal electroencephalogram without any ...
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Febrile seizures (FS) occur in 2–5% of children. Their pathogenesis is unknown. Elevated levels of prostaglandins (PG) have been found in cerebrospinal fluid after such seizures, and a third of all patients have recurrences. No safe ways of reducing the risk of recurrences have been found. The outcome has been shown in prospective studies to be good, by they have been linked to mesial temporal ...
متن کاملFebrile seizures.
BACKGROUND Febrile convulsions, or febrile seizures, are frequently encountered in paediatrics, and despite often being self limiting, these seizures strike fear in the hearts of patients' carers. OBJECTIVE This article reviews the assessment and management of febrile seizures in children. DISCUSSION The initial assessment of a child who convulses with fever should be directed at finding a ...
متن کاملFebrile seizures.
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عنوان ژورنال:
iranian journal of child neurologyجلد ۴، شماره ۲، صفحات ۳۷-۴۰
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